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*                        theophylline_project.mlxtran                          *
*                        December 23, 2017 at 17:06:02                         *
*                        Monolix version : 5.0.0                               *
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POPULATION PARAMETERS ESTIMATION _______________________________________________

Fixed Effects ----------------------------   s.e.(sa)  r.s.e.(%)     pvalue
ka_pop                        :       1.54      0.293       18.9           
V_pop                         :       32.5       1.24        3.8           
beta_V_lw70                   :      0.748      0.287       38.4    0.00915
Cl_pop                        :       2.82      0.235       8.36           
beta_Cl_lw70                  :      0.607      0.629        104      0.335

Standard Deviation of the Random Effects -
omega_ka                      :      0.621      0.148       23.9           
omega_V                       :     0.0987     0.0372       37.7           
omega_Cl                      :      0.264     0.0662       25.1           

Error Model Parameters -------------------
a                             :      0.579      0.129       22.2           
b                             :     0.0764     0.0339       44.3           

Elapsed time (seconds) :      1.5
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CORRELATION MATRIX OF THE ESTIMATES ____________________________________________

Fisher by Stochastic Approximation ---------------------------------------------
Correlation Matrix :
      ka_pop   1.00000
       V_pop   0.13780   1.00000
 beta_V_lw70  -0.01617   0.03147   1.00000
      Cl_pop  -0.04387  -0.12247   0.00034   1.00000
beta_Cl_lw70   0.00305  -0.00556  -0.12666   0.12286   1.00000
    omega_ka   0.04499   0.00542   0.12128  -0.00078  -0.03795   1.00000
     omega_V   0.05346   0.06366   0.16496   0.00060  -0.03341   0.13393   1.00000
    omega_Cl   0.00089  -0.00002  -0.04101  -0.03106  -0.01300  -0.03541  -0.23230   1.00000
           a   0.08512  -0.02766  -0.02640  -0.01197   0.04873  -0.00113   0.09950   0.03454   1.00000
           b  -0.09224   0.04911  -0.01684   0.00958  -0.03924  -0.04809  -0.18223  -0.02056  -0.86769   1.00000

                               min       max   max/min
Eigen values           :      0.13       1.9        15

Elapsed time (seconds) :    0.31
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INDIVIDUAL PARAMETERS ESTIMATION _______________________________________________

Individual Parameters Estimation by Conditional Mode ---------------------------
           min        Q1    median        Q3       max
ka :     0.678     0.992      1.35      2.09      5.85
V  :      26.5      28.7      32.4      34.8      38.9
Cl :      1.67      2.41      3.03      3.34      4.04

Elapsed time (seconds) :   0.006
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INDIVIDUAL PARAMETERS ESTIMATION _______________________________________________

Individual Parameters Estimation by Conditional Mode ---------------------------
           min        Q1    median        Q3       max
ka :     0.678     0.992      1.35      2.09      5.85
V  :      26.5      28.7      32.4      34.8      38.9
Cl :      1.67      2.41      3.03      3.34      4.04

Elapsed time (seconds) :   0.006
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